Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype.
|
23996088 |
2013 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
|
0.800 |
GeneticVariation
|
GWASCAT |
A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults.
|
25468567 |
2015 |
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex.
|
29296818 |
2017 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
|
0.800 |
GeneticVariation
|
GWASDB |
Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse.
|
24141364 |
2013 |
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
|
29632299 |
2018 |
Ph-Like Acute Lymphoblastic Leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
<i>GATA3</i> single nucleotide variant rs3824662 shows a strong association with Ph-like ALL (OR = 3.14).
|
30770347 |
2019 |
Ph-Like Acute Lymphoblastic Leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
The germline variant at rs3824662 in GATA3 is a risk locus for Philadelphia-like acute lymphoblastic leukemia (Ph-like ALL), the biological subtype of B-cell precursor (BCP)-ALL defined by a distinct gene expression profile and the presence of specific somatic aberrations including rearrangements of CRLF2.
|
30859636 |
2019 |
Ph-Like Acute Lymphoblastic Leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
The risk allele at rs3824662 was most frequent in Philadelphia chromosome (Ph)-like ALL but also conferred susceptibility to non-Ph-like ALL in AYAs.
|
25468567 |
2015 |
Ph-Like Acute Lymphoblastic Leukemia
|
|
0.040 |
GeneticVariation
|
BEFREE |
The rs3824662 risk allele was associated with somatic lesions underlying Ph-like ALL (CRLF2 rearrangement, JAK gene mutation and IKZF1 deletion) and with variation in GATA3 expression.
|
24141364 |
2013 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
The rs10828317 association was shown to be specifically associated with hyperdiploid ALL, whereas the rs3824662-associated risk was confined to nonhyperdiploid non-TEL-AML1 + ALL.
|
23996088 |
2013 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
The GATA3 rs3824662 A allele and AA genotype may be risk factors for the development of pediatric ALL especially B-ALL in the studied cohort of Egyptian patients.
|
27684731 |
2017 |
Childhood Acute Lymphoblastic Leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
In a genome-wide association study (GWAS) of 511 ALL cases and 6,661 non-ALL controls, we identified a susceptibility locus for Ph-like ALL (GATA3, rs3824662; P = 2.17 × 10(-14), odds ratio (OR) = 3.85 for Ph-like ALL versus non-ALL; P = 1.05 × 10(-8), OR = 3.25 for Ph-like ALL versus non-Ph-like ALL), with independent validation.
|
24141364 |
2013 |
Hyperdiploid B Acute Lymphoblastic Leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs10828317 association was shown to be specifically associated with hyperdiploid ALL, whereas the rs3824662-associated risk was confined to nonhyperdiploid non-TEL-AML1 + ALL.
|
23996088 |
2013 |
Acute lymphocytic leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs10828317 association was shown to be specifically associated with hyperdiploid ALL, whereas the rs3824662-associated risk was confined to nonhyperdiploid non-TEL-AML1 + ALL.
|
23996088 |
2013 |
Adult Acute Lymphocytic Leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs10828317 association was shown to be specifically associated with hyperdiploid ALL, whereas the rs3824662-associated risk was confined to nonhyperdiploid non-TEL-AML1 + ALL.
|
23996088 |
2013 |
Acute lymphocytic leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
The GATA3 rs3824662 A allele and AA genotype may be risk factors for the development of pediatric ALL especially B-ALL in the studied cohort of Egyptian patients.
|
27684731 |
2017 |
Adult Acute Lymphocytic Leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
The GATA3 rs3824662 A allele and AA genotype may be risk factors for the development of pediatric ALL especially B-ALL in the studied cohort of Egyptian patients.
|
27684731 |
2017 |
Hyperdiploid B Acute Lymphoblastic Leukemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
These SNPs are located at CDKN2A (rs3731217) and IKZF1 (rs4132601), genes frequently lost in ALL, and at CEBPE (rs2239633), ARID5B (rs7089424), PIP4K2A (rs10764338), and GATA3 (rs3824662), genes located on chromosomes gained in high-hyperdiploid ALL.
|
26575185 |
2015 |
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism rs10828317 is responsible for the N215S polymorphism in exon 7 of PIP4K2A, and rs3824662 localizes to intron 3 of the transcription factor and putative tumor suppressor gene GATA3.
|
23996088 |
2013 |
Encephalitis, St. Louis
|
|
0.010 |
GeneticVariation
|
BEFREE |
GATA3 rs3824662 is not associated with susceptibility to SLE either in adult or in pediatric patients; however, in pSLE patients, the heterozygous AC genotype could be considered a risk factor for LN.
|
30301440 |
2018 |
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
GATA3 rs3824662 is not associated with susceptibility to SLE either in adult or in pediatric patients; however, in pSLE patients, the heterozygous AC genotype could be considered a risk factor for LN.
|
30301440 |
2018 |
Lupus Nephritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
GATA3 rs3824662 is not associated with susceptibility to SLE either in adult or in pediatric patients; however, in pSLE patients, the heterozygous AC genotype could be considered a risk factor for LN.
|
30301440 |
2018 |